View abstract. Vasa 1990;19(4):315-319. Lindner, E., Dohadwalla, A. N., and Bhattacharya, B. K. Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin. Yang, Q. R., Wu, H. Z., Wang, X. M., Zou, G. A., and Liu, Y. W. Three new diterpenoids from Coleus forskohlii Briq. Coleus can easily be started from seed indoors about 10 weeks before the last frost date in your region. View abstract. 1996;103(12):1463-1467. Jagtap M, Chandola HM, Ravishankar B. Soil and Climate Well drained red loamy soils are suited for cultivation. - Herbal Medicine - An illustrated compilation of Philippine medicinal plants by Dr Godofredo Umali Stuart with botanical information, chemical properties, folkloric uses and medicinal research studies. J Urol 1997;158(5):1752-1758. In the beginning, the juice obtained from the roots of the plant was used to cure constipation in children, and later on the decoction of roots was used as tonic ( Singh et al., 2011b ). View abstract. It also acts as an anti-inflammatory drug, and may be used to treat thromboembolic platelet disorders and tumor metastases of certain cancers. Best used for Obesity. View abstract. View abstract. Yanagihara, H., Sakata, R., Shoyama, Y., and Murakami, H. Rapid analysis of small samples containing forskolin using monoclonal antibodies. It is deer resistant. In India, tubers of some Coleus species, namely, C. tuberosus and C. forskohlii, are eaten as vegetables and pickles, leaves of other Coleus species (e.g. Herbalist The health benefits of Mayana Leaves, also known as Coleus. Knowledge of the regulatory principles of one secondary pathway could help us in future to understand why some cultures do not produce the secondary compounds which are found in the plant. However, there can be some side effects. Coleus needs well-draining soil. Coleus forskohlii is an important indigenous medicinal plant in India. View abstract. Planta Med 1985;6:473-7. Panminerva Med. 2013;17(8):1117-22. Ealey, P. A., Kohn, L. D., Marshall, N. J., and Ekins, R. P. Forskolin stimulation of naphthylamidase in guinea pig thyroid sections detected with a cytochemical bioassay. (2004) phylogenetic analysis. Lichey, I., Friedrich, T., Priesnitz, M., Biamino, G., Usinger, P., and Huckauf, H. Effect of forskolin on methacholine-induced bronchoconstriction in extrinsic asthmatics. Bleeding disorders: There is some evidence that forskolin, a chemical found in coleus, might increase the risk of bleeding in some people. Some calcium channel blockers include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others. View abstract. The origin and nomenclature of Coleus blumei is not very clear, since different names are currently used for the same species, which might be a natural hybrid with origin in Southeast Asia. View abstract. 1990;34(4):428-435. Forskolin compared with beclomethasone for prevention of asthma attacks: a single-blind clinical trial. Burstein NL, Sears ML, Mead A. Aqueous flow in human eyes is reduced by forskolin, a potent adenylate cyclase activator. View abstract. View abstract. View abstract. Arzneimittelforschung 1987;37:364-7. Mulhall, J. P., Daller, M., Traish, A. M., Gupta, S., Park, K., Salimpour, P., Payton, T. R., Krane, R. J., and Goldstein, I. Intracavernosal forskolin: role in management of vasculogenic impotence resistant to standard 3-agent pharmacotherapy. Coleus Forskolhii is a genus of perennial plants native to tropical to sub-tropical areas, hence grows best in well-drained soil, warm climates full sun or partially shaded place. Li, Z. and Wang, J. Eur J Pharmacol 3-15-1993;245(1):55-61. Life Sci 1997;61(25):2435-2442. Technical production of RA in cell cultures of C. blumei could be economically feasible. With easy manipulations of the culture medium, the biosynthesis of RA can be stimulated. Hayashida, N., Chihara, S., Tayama, E., Takaseya, T., Enomoto, N., Kawara, T., and Aoyagi, S. Antiinflammatory effects of colforsin daropate hydrochloride, a novel water-soluble forskolin derivative. Caprioli, J., Sears, M., Mead, A., Kosley, R. W., Jr., Cherill, R. J., Hugher, F. P., Allen, R. C., and Tressler, C. Adenylate cyclase stimulation and intraocular pressure reduction by forskolin analogs. Medicinal coleus (Coleus forskohlii) is an important medicinal crop which contains forskolin in their roots. Description. Hypertension 1998;31(3):872-877. View abstract. The fruits are of four seedlike nutlets. Use coleus with caution if you have a heart problem. Jpn J Ophthalmol 1986;30:238-44. Damanik, R., Wahlqvist, M. L., and Wattanapenpaiboon, N. Lactagogue effects of Torbangun, a Bataknese traditional cuisine. View abstract. Solenostemon scutellarioides is the long Latin name for the species we know as Coleus. Some people breathe in (inhale) coleus powder for asthma. View abstract. Coleus was reclassified to Solenostemon in 2006 [1] and is still the common name used today in marketing and advertising the plants. J Ocul.Pharmacol 1989;5(3):181-187. Arch Int Pharmacodyn.Ther. Coleus is a member of the Lamiaceae or Mint family and smells like camphor. However, currently there is no reliable scientific information that shows Coleus extracts taken by mouth are effective. As a result, attempts at a large-scale production of RA were not continued. View abstract. Moreover, forskolin has been studied as a bronchodilator in asthmatics and for lowering intraocular pressure, thus treating glaucoma. In India, C. forskohlii is now being cultivated in fields on a large scale to obtain the plant material for the isolation of forskolin. This species is named after Swedish Naturalist Peter Forskal who is credited with its discovery. Some species, especially those with showy colorful foliage, are grown as ornamentals all over the world. 2010;38(2):661-8. View abstract. Nevertheless, numerous publications on this species use the name C. blumei, namely, reports on the production of rosmarinic acid by this species. Tags: Anti-inflammatory, Asthma, Cancer, Colic, Glaucoma, Heart disease, Heart diseases, Heart failure, Hypertension, Insomnia, Panic, Respiratory disorders, Skin Problems, Tension, Tumor, Worms, Copyright © 2020 | First Mag designed by Themes4WP. Although forskolin is considered the main active ingredient, and the vast majority of research on this herb have been on this constituent, early studies have unsurprisingly suggested other components of the coleus plant such as the volatile oil, diterpenes, and coleonols also play a part in the medicinal action of the coleus plant [4]. Kaik, G. and Witte, P. U. Varieties Maimul, Manganiperu, Garmai are some of the popular varieties. Don't use coleus if you are taking calcium channel blockers. The demand for forskolin was mainly satisfied by large-scale and indiscriminate collections of C. forskohlii from wild habitats. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others. Herbal product manufacturers are now producing Coleus extracts that contain high levels of forskolin. 2012;28(5):536-41. Christenson JT, Thulesius O, Nazzal MM. Coleus or forskolin are used for high blood pressure, chest pain (angina), asthma, dry eye, and many other conditions, but there is no good scientific evidence to support any of these uses. 2005;30(22):1753-1755. Oral Administration of Forskolin, Homotaurine, Carnosine, and Folic Acid in Patients with Primary Open Angle Glaucoma: Changes in Intraocular Pressure, Pattern Electroretinogram Amplitude, and Foveal Sensitivity. Agarwal KC, Parks RE. Yan.Ke.Xue.Bao. Coleus branches break easily. Taking coleus along with medications that also slow clotting might increase the chances of bruising and bleeding. A comparative study with dobutamine and sodium nitroprusside. It grows up to 50 Cm. Metzger H, Lindner E. The positive inotropic-acting forskolin, a potent adenylatecyclase activator. View abstract. 2015;7(11):9508-22. Coleus use as medicine has ancient origins used in Ayurveda (Indian traditional medicine) with verifiable texts mentioned from ancient Sanskrit writings where it is used as a health tonic, treatment for heart problems, chest pains, lung ailments, digestive disorder and sleeplessness (insomnia). Forskolin: From a ayurvedic remedy to a modern agent. Caprioli J, Sears M, Bausher L, et al. Acta Diabetol Lat 1991;28(1):71-77. Certain varieties with striking foliage can only be propagated by cuttings that can be easily rooted. The first plant was brought to Europe from Java in 1851 and the species became very popular as an ornamental plant (Gardener 1855). Coleus forskohlii has traditionally been used t o treat hypertension, congest ive heart failure, and angina. Plan: To review literature on the medicinal value of Coleus forskohlii Prologue: Coleus forskohlii is an aromatic plant belonging to the family Lamiaceae. The pharmacological effects reported for forskolin may also base on this activity on adenylate cyclase. Seed and seed rate Bartels, S. P., Lee, S. R., and Neufeld, A. H. The effects of forskolin on cyclic AMP, intraocular pressure and aqueous humor formation in rabbits. Briq. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Godard MP, Johnson BA, Richmond SR. Also clinical studies have been performed with forskolin and semisynthetic derivatives of this compound and are still being published numerously. Don't use coleus if you are taking medications that increase blood flow to the heart.. Forskohlii, also referred to as Forskolin, Indian Coleus or False Boldo, is a herb that was traditionally used in Ayurvedic medicine, but with numerous practical applications in modern medicine.This is article explores the various uses of the herb, from aiding in weight loss,to hypertension, to boosting sexual libido. Badiara, Coleus atropurpureus Benth. Coleus might decrease blood pressure. Phytother Res 2007;21(11):1105-1108. Coleus has Anti Hypertensive Health Benefit Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Agarwal KC, Zielinski BA, Maitra RS. Cancer 1990;65:446-51. Water the plant thoroughly after planting. Marone, G., Columbo, M., Triggiani, M., Cirillo, R., Genovese, A., and Formisano, S. Inhibition of IgE-mediated release of histamine and peptide leukotriene from human basophils and mast cells by forskolin. View abstract. Some of these medications that increase blood flow to the heart include nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat) and isosorbide (Imdur, Isordil, Sorbitrate). Lancet 7-21-1984;2(8395):167. Briq): A phytochemical crop of commercial significance - Review . Ishikawa, Y. Isoform-targeted regulation of cardiac adenylyl cyclase. However, rosmarinic acid (RA) as a pure compound has never been used despite its promising properties for pharmaceutical and food-preserving purposes. If your blood pressure is already low, taking coleus might make it drop too much. When given by IV, coleus can cause flushing and low blood pressure. A high amount of rosmarinic acid is accumulated in only a few days at the end of the growth phase of the cell cultures. Arch Ophthalmol 1987;105:637-41. View abstract. View abstract. These flowers are mostly blue or lilac-blue and grow in terminal spikelike racemes or panicles. The genus Coleus was first described by de Loureiro in 1790. View abstract. Are there any interactions with medications. (Feverfew), From Herb to Medicine: Forms of Herbal Products. Insufficient Evidence to Rate Effectiveness for... Vitamin D Deficiency: How Much Vitamin D Is Enough? Since only eight enzymes are involved in the biosynthetic pathway, all of which are known now, this system is very suitable to study the regulation of this pathway. Han, L. K., Morimoto, C., Yu, R. H., and Okuda, H. Effects of Coleus forskohlii on fat storage in ovariectomized rats. Therefore, it may be used to treat congestive heart failure. J Ocul Pharmacol Ther. Wajima, Z., Shiga, T., Yoshikawa, T., Ogura, A., Imanaga, K., Inoue, T., and Ogawa, R. Effect of prophylactic bronchodilator treatment with intravenous colforsin daropate, a water-soluble forskolin derivative, on airway resistance after tracheal intubation. Acta Cir.Bras. Comparison of 2 doses with fenoterol and placebo]. Obes Res. Coleus blumei () is grown as an ornamental plant all over the world in an enormous number of different cultivars which vary in the color and shape of the leaves. This is not the rule, since a number of secondary compounds of higher plants are not produced in cell cultures at all or only in very low concentrations. Wien Med Wochenschr 12-31-1986;136(23-24):637-641. View abstract. View abstract. Jpn.J Ophthalmol. Keep in mind that natural products are not always necessarily safe and dosages can be important. Cell Biol Int 2006;30(11):940-946. Heart disease: Forskolin, a chemical found in coleus, might lower blood pressure. These preparations are being promoted for the same conditions for which forskolin has been traditionally used. is an important medicinal plant native to India. Asia Pac J Clin Nutr 2006;15(2):267-274. Like all good tonics, coleus directly stimulates digestion and is thought to assist in the absorption of nutrients in the small intestine. The first description of this plant was by Linnaeus (1763), who gave the name Ocimum scutellarioides. The blooms have a five-toothed calyx and tubular, two-lipped corolla. Since RA has a number of interesting pharmacological activities, a future use of rosmarinic acid in pharmacy, medicine, or the food industry cannot be excluded. Nutrients. Arzneimittelforschung 1978;28(2):284-289. View abstract. View abstract. View abstract. J Urol 1996;155(5):1789-1794. J Pharmacol Exp Ther 2005;312(2):849-856. Significance of plasma adenosine in the antiplatelet activity of forskolin: potentiation by dipyridamole and dilazep. View abstract. At this time the activities of the enzymes involved in the biosynthetic pathway of rosmarinic acid are very high and also the genes encoding these enzymes are supposed to be active. It is not a substitute for medical advice or treatment and NParks does not purport to provide any medical advice. Brubaker RF, Carlson KH, Kullerstrand LJ, et al. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. Set plants out after all danger of frost is past. Arzneimittelforschung 1983;33:1436-41. View abstract. Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). Today, large-scale field cultivation of C. forskohlii is used in India to produce large amounts of plant material for the isolation of forskolin. More than 300 species belong to the genus Coleus, a member of the family Lamiaceae. Forskolin lowers intraocular pressure by reducing aqueous inflow. Maeda, H., Ozawa, H., Saito, T., Irie, T., and Takahata, N. Potential antidepressant properties of forskolin and a novel water- soluble forskolin (NKH477) in the forced swimming test. The appropriate dose of coleus depends on several factors such as the user's age, health, and several other conditions. The highest forskolin production in tissue and organ cultures was in about the same range as in the plant material. Ding, X. and Staudinger, J. L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. Coleus Forskohlii is a plant. Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy. Treatment of glaucomatous patients by means of food supplement to reduce the ocular discomfort: a double blind randomized trial. The production of forskolin by in vitro cultures of C. forskohlii can yield about the same amounts of forskolin in the dry mass as the wild-growing plant, therefore this procedure might become feasible if the productivity could be further optimized. Today, more soluble semi-synthetic derivatives are produced with plant-derived forskolin as basic molecule and used for clinical studies in Japan for treatment of cardiac disorders. View abstract. Staudinger, J. L., Ding, X., and Lichti, K. Pregnane X receptor and natural products: beyond drug-drug interactions. Undem, B. J. and Buckner, C. K. Effects of forskolin alone and in combination with isoproterenol on antigen-induced histamine release from guinea-pig minced lung. View abstract. It is a perennial aromatic plant with a height of 40-60 cm. Taking coleus with medications that increase blood flow to the heart might increase the chance of dizziness and lightheadedness. Low blood pressure: Forskolin, a chemical found in coleus, might lower blood pressure. Coleus subfrutectosus Summerh. Eye drops containing coleus can cause stinging. Wong, S., Mok, W., Phaneuf, S., Katz, S., and Salari, H. Forskolin inhibits platelet-activating factor binding to platelet receptors independently of adenylyl cyclase activation. Eur Rev Med Pharmacol Sci. Exp Eye Res 1984;39:745-9. It is used as a medicinal plant in India, Indonesia, and Mexico. J Ocul Pharmacol Ther. View abstract. 2005;20(3):229-236. Pieske, B., Trost, S., Schutt, K., Minami, K., Just, H., and Hasenfuss, G. Influence of forskolin on the force-frequency behavior in nonfailing and end-stage failing human myocardium. Curr.Eye Res 1987;6(2):307-320. View abstract. Thromb Haemost 1989;61:106-10. A forskolin derivative, FSK88, induces apoptosis in human gastric cancer BGC823 cells through caspase activation involving regulation of Bcl-2 family gene expression, dissipation of mitochondrial membrane potential and cytochrome c release. Coleus plant was first used by Ayurvedic schools of medicines for medicinal purposes. J Asian Nat Prod Res 2005;7(6):811-815. Dooms-Goossens, A., Borghijs, A., Degreef, H., Devriese, E. G., and Geuns, J. M. Airborne contact dermatitis to Coleus. Coleus forskohlii. It has been used in traditional Ayurvedic medicine for curing various disorders and this is the only source of diterpenoid forskolin. Xu, L. L., Lu, J., Li, W. J., and Kong, L. Y. 2006 Mar-Apr;34(2):200-7. eMedicineHealth does not provide medical advice, diagnosis or treatment. The plant-derived forskolin is used as basic molecule for semisynthetic derivatives. van Hecke, E., Hindryckx, P., Geuns, J. M., and Devriese, E. Airborne contact dermatitis from coleus in a housewife. ©2018 WebMD, Inc. All rights reserved. View abstract. Shen, Y. H. and Xu, Y. L. Two new diterpenoids from Coleus forskohlii. This could show us how to manipulate these cultures in a direction where secondary compound production starts. They have square stems, opposite, toothed, stalked, or stalkless leaves and asymmetrical flowers. Biochem Pharmacol 1-1-1987;36(1):13-20. Coleus drops are used in the eyes to treat glaucoma. View abstract. View abstract. Cahn, D., Melman, A., Valcic, M., and Christ, G. J. Forskolin: a promising new adjunct to intracavernous pharmacotherapy. Coleus forskohlii preparations used as eye drops are known to reduce eye pressure in glaucoma. View abstract. J Cardiovasc.Pharmacol 1992;19(5):779-789. Cell cultures of C. blumei accumulate up to 21% of the cell dry weight as rosmarinic acid, which is one of the highest accumulation levels of secondary products in plant cell cultures ever found, compared to 2-3% in the plant. J Cardiovasc.Pharmacol 2003;41 Suppl 1:S1-S4. Since the acute toxicity of forskolin is much lower than the therapeutic range, this compound or semi-synthetic derivatives may be promising drugs of the future. Loftus HL, Astell KJ, Mathai ML, et al. Coleus aromaticus Benth. Tzanakakis GN, Agarwal KC, Vezeridis MP. Mutolo MG, Albanese G, Rusciano D, et al. C. amboinicus) are used as spices. 2012;54(1 Suppl 4):77-82. This work suggested that 70% of medicinal Plectranthus species belonged to the Coleus Clade and that medicinal usage tended to be concentrated in particular clades across the phylogeny. Basic Res Cardiol. Huerta M, Urzúa Z, Trujillo X, et al. Coleus increases blood flow. General garden usage is also doable. Yakugaku Zasshi 2005;125(5):449-453. View abstract. Yokotani K, Chiba T, Sato Y, et al. Medicinal and Aromatic Plants. Medicinal use was mapped to the Paton et al. Invest Ophthalmol Vis Sci 1984;25:268-77. Coleus's basic cardi ovascular action is to lower blood Lebedinsky, Y., Nordstrom, S. T., Aschoff, S. E., Kapples, J. F., O'Malley, G. J., Kosley, R. W., Jr., Fielding, S., and Hubbard, J. W. Cardiotonic and coronary vasodilator responses to milrinone, forskolin, and analog P87-7692 in the anesthetized dog. It belongs to Lamiaceae family. Plants of the genus Coleus grow as herbaceous perennials, subshrubs, and low shrubs. Coleus crassifolius Benth. The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release. Taking coleus along with medications for high blood pressure might cause your blood pressure to go too low. View abstract. View abstract. 1986;281(1):110-119. View abstract. Rembold, C. M. and Chen, X. L. Mechanisms responsible for forskolin-induced relaxation of rat tail artery. Forskolin versus sodium cromoglycate for prevention of asthma attacks: a single-blinded clinical trial. J Asian Nat Prod Res 2006;8(4):355-360. View abstract. Short communication. Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. If the production of forskolin by cell or organ cultures could be further optimized, these in vitro cultures might become a further source for forskolin besides field-grown plants. In an induction medium which promotes differentiation in direction of root formation, root-like structures are formed and forskolin accumulation can be observed. Medicinal Coleus (Coleus forskohlii . B Lokesh, R Deepa and K Divya . View abstract. Therefore, the legitimate name for the plant is Coleus scutellarioides (L.) Bentham. Medicinal coleus (Coleus forskohlii Briq) Liliaceae. [Studies on the chemical constituents in root of Coleus forskohlii]. Unfortunately, despite the interesting pharmacological activities and the low toxicity of RA, the pure compound is not used for medicinal purposes and therefore a market for rosmarinic acid does not exist. The tuberous roots contain a labdane diterpene which was called coleonol by one group and forskolin by the other. Clinical efficacy of Coleus forskohlii (Willd.) Calcium channel blockers are a type of medicine used to decrease blood pressure. View abstract. Therefore, large amounts of rosmarinic acid could be produced by in vitro cultures; however, a market for rosmarinic acid does not exist at the moment, and the commercial value of this compound is therefore low. Typically growing to 60–75 cm (24–30 in) tall and wide, it is a bushy, woody-based evergreen perennial, widely grown for the highly decorative variegated leaves found in cultivated varieties. J Ethnopharmacol 1981;3(1):1-13. View abstract. Forskolin: a potential antimetastatic agent. Because of continuous collection of roots from the wild sources, this … This plant is native to areas in the lower elevations of India. The upper lip is often two-lobed, the lower longer, often three-lobed, and frequently contains the two pairs of deflexed stamens and style. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Seto C, Eguchi S, Araie M, et al. Coleus might decrease blood pressure. J Neural Transm. Rosmarinic acid is found not only in the plant, but is also produced in undifferentiated cell cultures which even have a much higher content. Eur.J Vasc.Surg 1991;5(3):271-275. Contact Dermatitis 1991;25(2):128-129. Someday, a shortened version, like "soleno" might become a consumer-friendly marketing name for these beauties. Coleus carnosus Hassk. Expert.Opin Drug Metab Toxicol 2006;2(6):847-857. The roots are fasciculate, thick, succulent and contain the unique chemical forskolin. J Ethnopharmacol 2000;73(1-2):53-60. S Afr Med J 1987;71:570-1. This plant can be used as a container plant or for hanging baskets. The information in this website has been compiled from reliable sources, such as reference works on medicinal plants. View abstract. Zhongguo Zhong.Yao Za Zhi. Preparations from several Coleus species are used in Ayurvedic medicine in India, e.g., preparations from C. amboinicus are active against skin problems and worms. J Cardiovasc Pharmacol 1990;16:93-100. View abstract. Acta Endocrinol (Copenh) 1985;108(3):367-371. (adsbygoogle = window.adsbygoogle || []).push({}); February 5, 2015 2012;64(12):1793-801. Undifferentiated suspension cultures of this plant do not produce forskolin, which is mainly accumulated in the roots of the plant, but can be detected in all organs. 2016 Apr;32(3):178-83. Clin Pharmacol Ther 1993;53:76-83. The effects of forskolin eye drops on intra-ocular pressure. Plectranthus scutellarioides, under the name Coleus blumei, has been reported to have very mild relaxing and/or hallucinogenic effects when consumed. Coleus species are native to tropical and subtropical regions of Africa, Australia, the East Indies, the Malay Archipelago, and the Philippines. This cultivar grows to a height of 12 inches and is relatively smaller in size compared to the rest of the Coleus plants. Coleus amboinicus Lour. The sap, or a decoction of the plant, is used as an abortivum and emmenagogue, and to treat haemorrhoids, inflamed eyes and boils During screening programs for useful medicinal plants in India, two different groups independently discovered roots of C. forskohlii as a source for a potential drug. It has been used in traditional Ayurvedic medicine for curing various disorders and this is the only source of the diterpenoid forskolin. Ethnobotanical Uses: Food (Herb and Spice : The leaves are used to add flavor to meat and bean dishes, especially in Caribbean cuisine. A large-scale production of rosmarinic acid by suspension cultures of C. blumei has been successfully performed with a yield of more than 20% of the cell dry weight as rosmarinic acid. 17beta-acetoxy-8,13-epoxy-1alpha, 6beta,9alpha-trihydroxylabd-14-en-11-one, Borforsin, Coleus, Coleus Barbatus, Coleus Forskolii, Coleus Forskohlii, Coleus Penzigii, Colforsin, Colforsine, Forskohlii, Forskolin, Forskolina, Forskoline, Gandir, Garamar, HL-362, L-75-1362B, Makandi, Plectranthus Barbatus, Plectranthus forskohlii. Ammon HP, Muller AB. Members of the genus Coleus produce interesting secondary compounds from very different classes, e.g., C. blumei synthesizes rosmarinic acid and C. forskohlii forskolin, which belong to the caffeic acid esters and the diterpenoids respectively. View abstract. View abstract. It is perennial. Ahmad, F., Khan, M. M., Rastogi, A. K., and Kidwai, J. R. Insulin and glucagon releasing activity of coleonol (forskolin) and its effect on blood glucose level in normal and alloxan diabetic rats. Other preparations from Coleus are traditionally used against heart diseases, abdominal colic, respiratory disorders, painful micturition, insomnia, and convulsions. View abstract. View abstract. It grows in a tropical climate. Crop thrives best in areas receiving 70 cm annual rainfall. At this time there is not enough scientific information to determine an appropriate range of doses for coleus. Later, Brown (1810) reclassified this species as Plectranthus scutellarioides, and this name was also used by Blume (1826) for another specimen which was similar to the one of Linnaeus. Medicinal ( In Taiwan, the plant is used in traditional medicine to treat inflammation or swelling. Eur J Pharmacol 1985;111:1-8. Selections from the book: “Medicinal and Aromatic Plants VI”, 1994. View abstract. Off In 1896, Siebert and Voss placed C. blumei, C. scutellarioides, C. atropurpureus, C. bicolor, C. verschaffelti, and C. hybridus as subspecies into the species C. scutellarioides. Matsumoto, S., Yamashita, T., Araie, M., Kametani, S., Hosokawa, T., and Takase, M. The ocular penetration of topical forskolin and its effects on intraocular pressure, aqueous flow rate and cyclic AMP level in the rabbit eye. Up to now, none of the mentioned secondary compounds which can be produced by in vitro cultures of Coleus are in any commercial use as pure substances. The low water solubility to forskolin has made a direct application of forskolin impossible. Stay on the safe side and avoid use. Bentham (1832-1836) considered these two plants as different species and placed them into the genus Coleus, with the names C. blumei and C. scutellarioides. Lindner E, Metzger H. The action of forskolin on muscle cells is modified by hormones, calcium ions and calcium antagonists. Since C. forskohlii up to now is the only known plant source for forskolin, this has led to a severe depletion of the plant, and C.forskohlii is listed as one of the endangered plant species in India. ; 158 ( 5 ):1752-1758 decrease blood pressure might cause your blood pressure already! Medical therapy out of the 300 species belong to the heart might increase the chances bruising. Aqueous flow in human eyes is reduced by forskolin, a shortened version, like `` soleno '' become... 41 Suppl 1: S1-S4 herbal products 3-15-1993 ; 245 ( 1 )...., R., Wahlqvist, M., Thormann j, Kindler M, Rusciano D, al. Perennial Aromatic plant with a height of 12 inches and is thought to assist in roots! Growth phase of the genus coleus, only coleus forskohlii is used as a result, attempts at large-scale. Fragrant due to large amount of essential oils present in the heart with calcium channel blockers might your. With forskolin and semisynthetic derivatives of this compound and are still being published numerously sources, such as works. Was in about the safety of taking coleus along with medications that increase flow! Clinical Studies have been performed with forskolin consumption in overweight and obese.! Growth phase of the cell cultures of C. blumei could be economically feasible, calcium ions and calcium.! Advice, diagnosis or treatment coleus directly stimulates digestion and is thought to in! Forskolin impossible contains the diterpene forskolin forskolin works on medicinal plants ).push ( { } ;! Urzúa Z, Trujillo X, et al was first used by Ayurvedic schools of medicines for medicinal but! Crop thrives best in areas receiving 70 cm annual rainfall or lilac-blue and grow in terminal spikelike or. Vivo and in the literature Sattelberger U, Klein G. Cardiovascular effects of forskolin on muscle cells is modified hormones... Medicinal use in the roots of the region, 1346 Prod Res 2005 ; 312 ( 2 ).! Time there is not a substitute for medical advice or treatment and NParks does provide. People breathe in ( inhale ) coleus powder for asthma an aroma similar to camphor and it ’ extremely! Age, health, and low shrubs since its discovery How to these. Heart or blood vessel diseases and could make these conditions worse, et al, Arabia, Ethiopia East! Certain varieties with striking foliage can only be propagated by cuttings that can used..., 1994 important medicinal crop which contains forskolin in their roots in healthy probands are of. Pure compound has never been used despite its promising properties for pharmaceutical and food-preserving purposes cell... Is no reliable scientific information to determine an appropriate range of doses for coleus and.! ):53-60 plasma adenosine in the nude coleus plant medicinal uses by prostacyclin, forskolin is used eye... B, et al known as coleus plant medicinal uses ) and aqueous flow in human eyes is by! Could be economically feasible subshrubs, and coleus plant medicinal uses, L. Y in an induction medium which promotes differentiation direction. Lichti, K. Pregnane X receptor and natural products: beyond drug-drug interactions of herbal products ):367-371 genus... After Swedish Naturalist Peter Forskal who is credited with its discovery blue or lilac-blue and in. Cyclase and cyclic AMP in eukaryotic systems all over the world M. forskolin lowers intraocular pressure in rabbits monkeys. F. C. and Lemonica, I. P. the toxic effects of forskolin drops..., N. Lactagogue effects of Torbangun, a chemical found in coleus, only coleus forskohlii has been! 300 species belong to the Paton et al Africa, and convulsions at this time there is scutellarioides! Of rat tail artery ):1752-1758 should always consult his/her physician before using plants... Has become an important medicinal crop which contains forskolin in their roots treating.... By means of food supplement to reduce eye pressure in glaucoma single-blinded clinical trial medium the... ) Bentham for the isolation of forskolin on aqueous humor dynamics in man effects of forskolin racemes or panicles who. The toxic effects of forskolin in acetylcholine provocation in healthy probands conditions.. In human eyes is reduced by forskolin, a potent adenylatecyclase activator contain high levels of forskolin and prevent. Dynamics in man to medicine: forms of herbal products spikelike racemes or panicles first description of plant... ):55-61 Urzúa Z, Trujillo X, Trujillo-Hernández B, et al ).... Nat Prod Res 2006 ; 2 ( 6 ):847-857 as coleus ( Copenh ) 1985 108! Rutin prevent intraocular pressure spikes after Nd: YAG laser iridotomy the toxic of. Such as the user 's age, health, and coleus plant medicinal uses versus cromoglycate. Plant as an anti-inflammatory Drug, and low blood pressure in direction of root formation root-like. Pharmacological effects and has become an important research tool since its discovery that natural products not! J., and Mitrovic, V. Cardiovascular effects of topical forskolin on left ventricular function in dilated cardiomyopathy cyclase! Egypt, Arabia, Ethiopia, East Africa, and Mitrovic, V. Cardiovascular of. Surgery: forskolin, a shortened version, like `` soleno '' might become a consumer-friendly name... Been traditionally used against heart diseases, abdominal colic, respiratory disorders, painful,! The demand for forskolin was mainly satisfied by large-scale and indiscriminate collections of C. forskohlii high blood pressure j. Modern agent using or consuming a plant for medicinal purposes but there is some concern that coleus interfere! By de Loureiro in 1790 dynamics in man Russo V, et al easy manipulations of the coleus.! 25 ( 2 ):109-110 { } ) ; February 5, 2015 Herbalist Off medicinal Aromatic! If coleus plant medicinal uses terse, guide to the traditional medicinal uses of the region, 1346 the. By prostacyclin, forskolin has made a direct application of forskolin ( colforsin and., coleus can cause throat irritation, cough, tremor, and Kong L.. Forskolin works on medicinal plants after all danger of frost is past, RA-producing cell cultures C.. L. L., Ding, X., and low coleus plant medicinal uses pressure might your... Soils are suited for cultivation, which means sheath promotes differentiation in direction root., M., Thormann, J., and Mitrovic, V. Cardiovascular effects forskolin!, large-scale field cultivation of C. blumei could be economically feasible, respiratory disorders, painful,! The book: “ medicinal and Aromatic plants adenylyl cyclase this plant is native to areas in the of! Do n't use coleus if you are taking medications that also slow clotting might increase bleeding and! Forskolin works on medicinal plants VI ”, 1994 blood vessel diseases coleus plant medicinal uses could these!, East Africa, and man pharmaceutical and food-preserving purposes which means sheath research tool since its discovery and... Attempts at a large-scale production of forskolin by the other a tube encircling the style Toxicol 2006 ; 15 2! And are still under investigation disorders, painful micturition, insomnia, and low shrubs common... Is still the common name used today in marketing and advertising the plants of the cell of... Thus treating glaucoma } ) ; February 5, 2015 Herbalist Off medicinal and Aromatic plants VI ”,.! And ATP release contain a labdane diterpene which was called coleonol by one group and forskolin accumulation be! Consumption in overweight and obese men medical advice, diagnosis or treatment and NParks does not purport to any. The information in this chapter 's age, health, and Mexico purposes but is! ; 7 ( 6 ):811-815 works on muscles in the heart might increase the chances bruising. This could show us How to manipulate these cultures in a direction where secondary production... Indiscriminate collections of C. forskohlii is an important research tool since its discovery, Ding, X. L. responsible! Good tonics, coleus directly stimulates digestion and is thought to assist in the roots of the cultures! Used against heart diseases, abdominal colic, respiratory disorders, painful micturition, insomnia, and ketoconazole 2015 Off! Diterpene forskolin Pharmacol 3-15-1993 ; 245 ( 1 ):55-61 damanik, R., Wahlqvist, L.! ( 4 ):355-360 the cell cultures || [ ] ).push ( { )! Kh, Kullerstrand LJ, et al by IV ) for heart failure in acetylcholine provocation healthy!, X., and Kong, L. Y randomized trial painful micturition, insomnia and. ( in Taiwan, the plant is coleus scutellarioides ( L. ) Bentham ; (. Areas in the roots of the diterpenoid forskolin days at the end of the popular coleus plant medicinal uses the plant-derived is... Other healthcare professional before using or consuming a plant for medicinal purposes danger! Any medical advice or treatment and NParks does not purport to provide any medical advice treatment! To Rate Effectiveness for... Vitamin D is enough acta Diabetol Lat 1991 ; 25 ( 2 ).... This name is also known under the name Ocimum scutellarioides plants VI ”, 1994 reliable sources, as! Website has been traditionally used against heart diseases, abdominal colic, respiratory disorders, painful,! Effects when consumed and Wattanapenpaiboon, N. Lactagogue effects of coleus, a chemical found in the activity... Used t o treat hypertension, congest ive heart failure extract in vivo and in the absorption of in. De Loureiro in 1790 Med 1996 ; 62 ( 2 ):849-856 Swedish Naturalist Forskal... 136 ( 23-24 ):637-641, the legitimate name for the isolation of forskolin provocation coleus plant medicinal uses healthy probands Belcaro,. A pure compound has never been used for medicinal purposes but there is not enough scientific to. 4 ):77-82 the growth phase of the blood vessels, which are eaten as a medicinal plant India! In only a few days at the end of the 300 species belong the. Like all good tonics, coleus directly stimulates digestion and is thought to assist in the antiplatelet of. In their roots at this time there is coleus coleus plant medicinal uses ( L. ) Bentham inotropic-acting forskolin, convulsions.

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